To mitochondrial cytochrome oxidase, it prevents the utilization Hydrogen cyanide acts as a cellular asphyxiant.Vomiting followed in some cases by coma and death. Produce eye irritation, headache, confusion, nausea, and Exposure to lower concentrations of hydrogen cyanide may.Hydrogen cyanide is highly toxic by all routes of exposureĪnd may cause abrupt onset of profound CNS, cardiovascular,Īnd respiratory effects, leading to death within minutes.Oxidizers, acids, sodium hydroxide, calcium hydroxide, sodiumĬarbonate, caustic substances, and ammonia. Or other serious health effects or symptoms which could impairĪn individual's ability to take protective action) = 10 ppm Physical PropertiesĪt >l ppm inadequate warning for acute or chronic exposureįlammable range: 5.6% to 40% (concentration Up to 1 hour without experiencing or developing irreversible Is believed that nearly all individuals could be exposed for Guideline) (maximum airborne concentration below which it (ceiling) = 10 ppm (skin) (averaged over 15 minutes) Hydrogen cyanide gas isĪ by-product of coke-oven and blast-furnace operations.Įlectroplating mining and in producing synthetic fibers, It is also produced by enzymatic hydrolysis It may be generatedīy treating cyanide salts with acid, and it is a combustionīy-product of nitrogen-containing materials such as wool, Of ammonia- methane mixtures under controlled conditions andīy the catalytic decomposition of formamide. Hydrogen cyanide is manufactured by oxidation Molten cyanide salts, resulting in large surface-area burns.Ĭhildren are more vulnerable to toxicantsĪbsorbed through the skin because of their relatively larger In liquid cyanide or cyanide solutions or from contact with Have been from industrial accidents involving partial immersion Most cases of toxicity from dermal exposure After skinĮxposure, onset of symptoms may be immediate or delayed forģ0 to 60 minutes. Is rapid and contributes to systemic poisoning. They have greater lung surface area:body weight ratios and Hydrogen cyanide as adults may receive larger doses because Odor is a genetic trait (20% to 40% of the general populationĬannot detect hydrogen cyanide) also, rapid olfactory fatigueĬan occur. The odor of hydrogen cyanide is detectable atĢ-10 ppm (OSHA PEL = 10 ppm), but does not provide adequate Routes of Exposure Inhalationįrom the lungs symptoms of poisoning begin within seconds Hydrogen cyanide has a faint, bitter almond odorĪnd a bitter, burning taste. The vapor is flammable and potentiallyĮxplosive. Is very volatile, producing potentially lethal concentrationsĪt room temperature. Exposure byĬyanide is a colorless or pale-blue liquid (hydrocyanic acid) Īt higher temperatures, it is a colorless gas. Or with direct contact with solutions, especially at highĪmbient temperatures and relative humidity. Occur through intact skin if vapor concentration is high
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